Custom Enzymes and Inhibitors
Selleck Chemical LLC Afatinib (BIBW2992) 5mg 850140-72-6
Afatinib (BIBW2992) inhibits EGFR/ErbB irreversibly in vitro with IC50 of 0.5, 0.4, 10, 14, 1 nM for EGFRwt, EGFR L858R , EGFR L858R/T790M ErbB2 (HER2) and ErbB4 (HER4), respectively. Afatinib induces autophagy. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Tanespimycin (17-AAG) 25mg 75747-14-7 CP127374, NSC-330507, KOS 953
Tanespimycin (17-AAG, CP127374, NSC-330507, KOS 953) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Tanespimycin (17-AAG) induces apoptosis, necrosis, autophagy and mitophagy. Phase 3. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC SU11274 25mg 658084-23-2 PKI-SU11274
SU11274 (PKI-SU11274) is a selective Met (c-Met) inhibitor with IC50 of 10 nM in cell-free assays, no effects on PGDFR?, EGFR or Tie2. SU11274 induces autophagy, apoptosis and cell cycle arrest. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC SB525334 100mg 356559-20-1
SB525334 is a potent and selective inhibitor of TGF? receptor I (ALK5) with IC50 of 14.3 nM in a cell-free assay, 4-fold less potent to ALK4 than ALK5 and inactive to ALK2, 3, and 6. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC GSK690693 50mg 937174-76-0
GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM in cell-free assays, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. GSK690693 also potently inhibits AMPK and DAPK3 from the CAMK family with IC50 of 50 nM and 81 nM, respectively. GSK690693 affects Unc-51-like autophagy activating kinase 1 (ULK1) activity, robustly inhibits STING-dependent IRF3 activation. Phase 1. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC GSK690693 10mg 937174-76-0
GSK690693 is a pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 2 nM/13 nM/9 nM in cell-free assays, also sensitive to the AGC kinase family: PKA, PrkX and PKC isozymes. GSK690693 also potently inhibits AMPK and DAPK3 from the CAMK family with IC50 of 50 nM and 81 nM, respectively. GSK690693 affects Unc-51-like autophagy activating kinase 1 (ULK1) activity, robustly inhibits STING-dependent IRF3 activation. Phase 1. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Tozasertib (VX-680, MK-0457) 25mg 639089-54-6
Tozasertib (VX-680, MK-0457) is a pan-Aurora inhibitor, mostly against Aurora A with Kiapp of 0.6 nM in a cell-free assay, less potent towards Aurora B/Aurora C and 100-fold more selective for Aurora A than 55 other kinases. The only exceptions are Fms-related tyrosine kinase-3 (FLT-3) and BCR-ABL tyrosine kinase, which are inhibited by the Tozasertib with both Ki of 30 nM. Tozasertib induces apoptosis and autophagy. Phase 2. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Tanespimycin (17-AAG) 100mg 75747-14-7 CP127374, NSC-330507, KOS 953
Tanespimycin (17-AAG, CP127374, NSC-330507, KOS 953) is a potent HSP90 inhibitor with IC50 of 5 nM in a cell-free assay, having a 100-fold higher binding affinity for HSP90 derived from tumour cells than HSP90 from normal cells. Tanespimycin (17-AAG) induces apoptosis, necrosis, autophagy and mitophagy. Phase 3. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Medchemexpress LLC Temsirolimus-Solid W/Slvnt | HY-50910-10MM SOLID/SLVNT
Temsirolimus-Solid W/Slvnt
Biochain Institute Inc Placenta Ribonuclease Inhibitor, 5000 units/PK
BioChain offers the most used enzymes in molecular biology and biochemistry, such as DNase I, RNase A, with premium quality and at the most competitive price.
Apexbio Technology LLC Potent and selective Aurora A Kinase inhibitor 1028486-01-2. MFCD16621243
Potent and selective Aurora A Kinase inhibitor 1028486-01-2. MFCD16621243
Selleck Chemical LLC Perifosine (KRX-0401) 5mg 157716-52-4 NSC639966
Perifosine (KRX-0401, NSC639966) is a novel Akt inhibitor with IC50 of 4.7 ?M in MM.1S cells, targets pleckstrin homology domain of Akt. Phase 3. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC U0126-EtOH 100mg 1173097-76-1
U0126-EtOH is a highly selective inhibitor of MEK1/2 with IC50 of 0.07 ?M/0.06 ?M in cell-free assays, 100-fold higher affinity for ?N3-S218E/S222D MEK than PD98059. U0126 inhibits autophagy and mitophagy with antiviral activity. *For Research & Development use only. Product is not intended for drug, household, or human consumption.